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. 2021 Jun 21;18:140. doi: 10.1186/s12974-021-02183-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Chemokine receptor levels. A, C, E, and G The proportion of macrophages (A, E, G)/microglia (C) that express CCR2, CCR5, or CXCR4 receptors. B, D, F, and H Mean fluorescent intensity (MFI) indicates the levels of expression of CCR2, CCR5, or CXCR4 in macrophages. A, B Hypothalamic macrophages CD11b+CD45^high; C, D hypothalamic microglia CD11b+CD45^low; E, F visceral fat macrophages F4/80+CD11b+; G, H Peritoneal cavity (PEC) macrophages F4/80+CD11b+. The proportion of CCR2-positive cells increases in the hypothalamic macrophages and microglia, while the proportion of CCR5+ macrophages increases in the adipose tissue. PEC macrophages increase proportions of CCR2-, CCR5-, and CXCR4-positive cells. Statistical significance (*) between Ctr (gray bars,) and HFD (black bars) were determined by Student’s T test followed by Tukey’s post hoc test