Fig. 1.

Mutational Signatures from RNA Sequencing of Tissues with and without Ovarian Cancer (OC). a The four mutational signatures according to trinucleotide context in the Mayo Clinic and TCGA OC tumors combined. b Heatmap of the cosine similarity of the four mutational signatures compared against the reference Catalogue of Somatic Mutations in Cancer (COSMIC) signatures. COSMIC signatures are grouped on the x-axis by using hierarchical clustering using the average method according to their cosine similarities. Mutational signature A has a high cosine similarity against COSMIC mutational signature 10 and it is denoted in red