Figure 2.

Structures of perampanel analogs

Perampanel and compounds 2 and 3 are shown in gray. Cyanophenyl derivatives of 2 building into S3–S4 are shown in lime. Uracil derivatives of 3 building into S3–S4 are shown in green. The benzyloxy uracil, 14, and its derivatives are shown in blue. The cyclopropyl uracil analog, 31, and piperazin-2-one uracil analog, 50, are shown in orange and red, respectively.