Figure 4.

Structures of perampanel analogs binding to the active site of M^pro

Inhibitors are shown as sticks and M^pro is shown in lilac. Compound numbers are shown in black in each panel (bottom left) and subsite labels are shown in blue. 11 (A) is shown in is shown in teal. 6 (B) is shown in purple with Gln¹⁹² of the complex with 5 (7L11) in cyan. 29 (C) is shown in magenta with the S5 loop of 11 shown in cyan. 25 (D) is shown in dark purple. 14 (E, 7L12) is shown in orange with Pro¹⁶⁸ of the complex with 11 shown in cyan. 16 (F) is shown in yellow with Met¹⁶⁵ and Leu¹⁶⁷ of 14 (7L12) and 11 shown in magenta and cyan, respectively. 19 (G) is shown in dark purple with Met¹⁶⁵ of 14 (7L12) shown in cyan. 21 (H, 7L13) is shown in green. 26 (I, 7L14) is shown in pink with the S5 loop of 19 shown in cyan. 50 (J) is shown in brown.