Figure 3:
Three-dimensional structure of LSD1-CoREST complex showing the unique architecture of two different binding/active sites for the development of specific inhibitors of LSD1 with implications in SCLC. The same color scheme was used to represent linear domain organization (upper part) and subsequent domains in the three-dimensional cartoon model. The structural model was generated using PyMOL, and structure coordinates were taken from Protein Data Bank (PDB ID: 2IW5) [193].