TABLE 3.

Effects of selected quinolin-4(1H)-imines against promastigotes and intramacrophagic amastigotes of L. major and L. amazonensis

Compound	Mean IC50 ± SD (μM) (SI) againsta:
	Promastigotes		Intramacrophagic amastigotes
	L. major	L. amazonensis	L. major	L. amazonensis
1d	0.5 ± 0.1	8.7 ± 1.6	3.9 ± 1.1 (2.6)	2.8 ± 1.1 (3.6)
1g	0.8 ± 0.1	3.4 ± 0.8	3.4 ± 0.9 (2.8)	3.5 ± 1.3 (2.7)
1h	0.6 ± 0.2	4.9 ± 1.4	2.6 ± 0.9 (3.8)	2.7 ± 0.9 (3.7)
1n	0.75 ± 0.01	2.4 ± 0.6	2.3 ± 1.1 (2.9)	2.3 ± 0.4 (2.9)

^aL. major and L. amazonensis promastigotes and intramacrophagic amastigotes were incubated for 24 h with serial dilutions of selected quinolin-4(1H)-imines. IC₅₀, half-maximal inhibitory concentration; SI, selectivity index (ratio between CC₅₀ and IC₅₀ values).