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. 2021 Jun 17;65(7):e02566-20. doi: 10.1128/AAC.02566-20

TABLE 1.

Antiviral activities of nsP1 inhibitors against CHIKV and SFV replication in CPE reduction assays

Compound CHIKV
SFV
EC50 (μM)a CC50 (μM)b EC50 (μM) CC50 (μM)
FHA 0.7 ± 0.08 >250 3.9 ± 3.5 >250
FHNA 1.2 ± 0.03 >250 5.2 ± 3.2 >250
CHVB-066 0.6 ± 0.1 25 NAc 25
CHVB-032 3.4 ± 0.3 >100 NA >100
MADTP-372 2.7 ± 0.2 >100 NA >100
Sinefungin 184.9 ± 38.4 >1,000 NA >1,000
a

EC50, the concentration of a compound that reduces virus-induced CPE by 50%.

b

CC50, the concentration of a compound that reduces cell viability by 50%.

c

NA, not active.