TABLE 1.

Examples of efflux pumps and the role they play in reducing susceptibility to various compounds and the Acinetobacter spp. in which they were first described

Efflux family	Example	Reduced susceptibility	Acinetobacter sp.	Reference(s)
MFS	CraA	Chloramphenicol	A. baumannii	25
	AmvA	Erythromycin	A. baumannii	26
	AbaF	Fosfomycin	A. baumannii	28
	AbaQ	Quinolones	A. baumannii	29
	TetA	Tigecycline	A. baumannii	30
	CmlA	Chloramphenicol	A. baumannii	31
MATE	AbeM	Fluoroquinolones	A. baumannii	51
ABC	A1S_0536	Erythromycin	A. baumannii	21
	A1S_1535	Gentamicin, chloramphenicol	A. baumannii	21
	MacAB-TolC	Potentially macrolides and tigecycline	A. baumannii	47
SMR	AbeS	Chloramphenicol, fluoroquinolones, novobiocin, erythromycin	A. baumannii	34
	QacE	Quaternary ammonia compounds	A. baumannii	39 – 41
PACE	AceI	Chlorhexidine	A. baumannii	53
	A1S_1503	Acriflavine	A. baumannii	54
RND	AdeABC	Aminoglycosides, trimethoprim, chloramphenicol, fluoroquinolones, tetracyclines, pentamide	A. baumannii	61, 69
	AdeDE	Amikacin, ceftazidime, chloramphenicol, ciprofloxacin, erythromycin, meropenem, rifampin, tetracycline	A. pittii	77
	AdeFGH	Chloramphenicol, trimethoprim, tetracycline-tigecycline, clindamycin; fluoroquinolones	A. baumannii	78
	AdeIJK	β-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolones, fusidic acid, novobiocin, rifampin, trimethoprim	A. baumannii	85
	AdeXYZ	NA	A. baylyi	90
	CzcABCD	Heavy metals such as copper	A. baumannii	23
	AbeD	Ceftriaxone, gentamicin, rifampin, tobramycin, benzalkonium chloride	A. baumannii	92
	ArpAB	Amikacin, tobramycin	A. baumannii	93
	AcrAB	Colistin, tobramycin, acriflavin	A. nosocomialis	95