FIG 4.

Distribution of arsenic and cadmium susceptibility levels and associated resistance determinants in 422 Staphylococcus saprophyticus isolates as determined by in silico analysis. Phylogenetic tree was constructed based on core-genome single-nucleotide polymorphisms without recombination. Phylogenetic tree was visualized using a Microreact web tool. Susceptibility levels to arsenic were classified as follows: susceptible, ≤400 mg/liter; intermediate, 800 mg/liter; resistant, ≥1,600 mg/liter. Susceptibility levels to cadmium were classified as follows: susceptible, ≤50 mg/liter; intermediate, 100 mg/liter; resistant, ≥200 mg/liter. *, all isolates in the collection carried arsRBC; #, all isolates in the collection carried copABZ. Data in interactive format are accessible at https://microreact.org/project/uDDq7sLSj3n1Fax6iw8NrY.