FIG 1.

Overview of the pharmacogenetic landscape in the Gabonese population. (a) Across the 21 pharmacogenes analyzed, a total of 347 different variants were identified, of which 309 were exonic. The majority of exonic variants resulted in amino acid exchanges (missense) or were synonymous. (b) Stacked column plot showing the number of variants per variant class per gene. Note that variant numbers differed >10-fold between genes. (c) The majority of variants were rare, with minor allele frequencies (MAFs) of <5%. (d) On average, each individual in the Gabonese cohort harbored between 71 and 119 variants in the analyzed pharmacogenes combined (mean ± standard deviation [SD], 87.3 ± 9.2). Pgx, pharmacogenetic.