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. 2021 Jun 21;10(1):1930391. doi: 10.1080/2162402X.2021.1930391

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© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Comparison of the expression of TIGIT, PD-1, CD73 and CD39 on CD8⁺ T cells in pAML, rAML and lrAML

The expression of PD-1, TIGIT, CD73 and CD39 was analyzed on CD8⁺ T cells in PB (A) and/or BM samples (B) from patients with pAML (PB, black circles, n = 20; BM, black triangles, n = 24), lrAML (PB, blue circles, n = 10; BM, blue triangles, n = 10), and rAML (PB, red circles, n = 8, BM, red triangles, n = 9), and of healthy donors (HDs) (PB, white circles, n = 12). (C) Summary data are shown comparing the frequency of TIGIT⁺CD73⁻CD8⁺ T cells and the expression of PD-1 and CD39 on this population in PB from HDs, pAML, IrAML, and rAML patients. (D) Pie Charts showing the distribution of subsets expressing combinations of TIGIT, PD-1, and CD39 on CD73⁺ or CD73⁻ CD8⁺ T cells from HDs, pAML, IrAML and rAML patients. P values were obtained by ANOVA and Kruskal-Wallis test. *P < .05, **P < .01, ***P < .001.