Table 3.

Predictors of surgical/endoscopic interventions and immunosuppressive therapy.

	Need for surgical / endoscopic interventions				Need for immunosuppressive therapy
	Univariable analysis		Multivariable analysis		Univariable analysis		Multivariable analysis
	HR [95% CI]	p-value	HR [95% CI]	p-value	HR [95% CI]	p-value	HR [95% CI]	p-value
Age	1.0 [1.0–1.1]	0.73			1.0 [1.0–1.1]	0.86
Male gender	0.9 [0.4–2.1]	0.88			1.3 [0.6–2.7]	0.50
UC diagnosis	1.2 [0.6–2.7]	0.62			0.9 [0.4–1.7]	0.68
Age of IBD onset	1.0 [1.0–1.1]	0.71			1.0 [1.0–1.1]	0.97
Pancolitis	0.5 [0.2–1.0]	0.07	0.5 [0.2–1.1]	0.09	0.5 [0.2–01.0]	0.04	2.0 [1.0–4.1]	0.06
Family history of IBD	1.7 [0.8–3.7]	0.20			1.4 [0.7–2.9]	0.32
Primary sclerosing cholangitis	2.1 [0.6–7.0]	0.24			1.0 [0.2–4.2]	0.99
Backwash ileitis	1.0 [0.3–3.4]	0.99			0.1 [0.4–2.9]	0.81
Pre-colectomy IMM use	1.2 [0.5–2.9]	0.72			1.2 [0.5–2.6]	0.71
Pre-colectomy biologic use	0.7 [0.3–1.7]	0.45			0.9 [0.5–1.9]	0.81
Disease activity as IPAA indication	0.9 [0.3–2.7]	0.88			0.7 [0.3–1.8]	0.44
Two-stage IPAA	1.6 [0.7–3.9]	0.28			1.6 [0.7–3.5]	0.23
Pre-pouch ileitis	4.3 [1.8–10.2]	0.001	4.1 [1.7–9.9]	0.002	5.1 [2.2–11.7]	0.0002	5.0 [2.2–11.6]	0.0002

IBD, inflammatory bowel disease; UC, ulcerative colitis; IPAA, ileal pouch-anal anastomosis, IMM, immunomodulator; HR, hazard ratio; CI, confidence interval.

Bold numbers represents statistically significant results.