(A) X-ray (left) and thresholded (right) images of the lumbar spine (L4–L6). (B) The average change of lumbar BMD (left) and BMC (right) from baseline to 9 days post-MI. Overall, average lumbar BMD and BMC of MI mice decreased from baseline to 9 days post-MI, and untreated mice exhibited greater changes than β3-AR antagonist treated mice. * denotes significant change (p ≤ .05) from baseline to 9 days post-MI. β3-AR, beta 3-adrenergic receptor; BMC, bone mineral content; BMD, bone mineral density; MI, myocardial infarction