Skip to main content
. 2021 Jun 8;12:705260. doi: 10.3389/fimmu.2021.705260

Figure 3.

Figure 3

Schematic diagram regarding CD2/CD58/CD48/CD59 system, CD2-CD58 immobilization in T cell activation, and IL-12/IFN-γ feedback loop. (A) Specific differences of reciprocal adhesion molecule between human and murine in the CD2/CD58/CD48/CD59 system. CD2 and CD244 (2B4) are presented at the surface of T/NK cells in human and murine. Specifically, CD2-CD58 is the principal ligand-receptor pair. CD48 and CD59 are two additional and low-affinity ligands of CD2 in human. The CD48 receptor binds both CD2 and CD244, while the CD58 gene is absent in murine. (B) The immobilization of CD2-CD58 following T cell activation. This process consists of three important features, increased CD2 surface expression, the high affinity of CD2-CD58, and rapidly lateral mobility; a series of conformational changes is beneficial to strengthen intercellular adhesion and aid recognition. (C) The important role of CD2-CD58 interaction in the IL-12/IFN-γ positive feedback loop between monocytes and activated T cells.