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Tumor cells evade immune surveillance by regulating the expression of CD58 on the membrane surface and sCD58 in the microenvironment. PI-PLC, phosphatidylinositol-specific phospholipase C; ATRA, all-trans retinoic acid; UV, ultraviolet; PMA, phorbol-12-myristate-13-acetate; APC, antigen-presenting cell.
