Skip to main content
. Author manuscript; available in PMC: 2021 Nov 3.
Published in final edited form as: Cell Metab. 2020 Oct 8;32(5):726–735.e5. doi: 10.1016/j.cmet.2020.09.008

Figure 3. Short term (90-min) lipid infusion in normal chow fed rats during a HE clamp alters muscle substrate preference (VPDH/VCS) but does not affect whole body or muscle-specific insulin sensitivity.

Figure 3.

A. Lipid infusion during a HE clamp in normal chow fed rats does not alter insulin-stimulated muscle glucose uptake. B. Lipid infusion does not alter insulin-stimulated muscle glucose transport (2-DG uptake), measured in soleus. C-D. Lipid infusion lowers insulin-stimulated VPDH/VCS by 50% in soleus and quad muscles. E. Lipid infusion does not change muscle AKT phosphorylation, measured in quad. Muscle acetyl-CoA content trends to an increase with lipid infusion but other metabolites are unchanged. Data are represented as mean ± SEM.