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Small molecule modifications are generally designed on the 3’-end of the siRNA sense strand. (a) Molecular design of representative lipid-conjugated siRNAs. Adapted with permission.[55] Copyright 2007, Springer Nature. (b) Schematic illustration of triantennary N-acetylgalactosamine-conjugated siRNA. GalNAc, N-acetylgalactosamine. Adapted with permission.[57] Copyright 2014, American Chemical Society.
