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. Author manuscript; available in PMC: 2021 Jun 22.
Published in final edited form as: Adv Ther (Weinh). 2020 Feb 13;3(3):1900206. doi: 10.1002/adtp.201900206

Figure 6.

Figure 6.

Polymer-conjugated nucleic acid via the click reaction between dibenzocyclooctyne (DBCO) and azide. (a) Conjugation between DBCO-functionalized RNA and azide-containing block copolymer. Adapted with permission.[62b] Copyright 2019, American Association for the Advancement of Science. (b) Formulation process of the hybridized complex between siRNA and DNA-grafted-polycaprolactone (PCL) (DNA-g-PCL). Before the hybridization step, DBCO-functionalized DNA was first conjugated with azide-decorated PCL. Adapted with permission.[64] Copyright 2018, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.