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. Author manuscript; available in PMC: 2021 Jun 22.
Published in final edited form as: Adv Ther (Weinh). 2020 Feb 13;3(3):1900206. doi: 10.1002/adtp.201900206

Figure 8.

Figure 8.

(a) One-step self-assembly of oligonucleotide nanoparticles. Six single-stranded DNA altogether self-assemble into tetrahedral structure. Arrowhead stands for the 5’-end of each DNA strand, with each color corresponding to one of the six edges of the tetrahedron. Meanwhile, the design allows site-specific hybridization of siRNA to the tetrahedron edge. (b) Atomic force microscopy image of the tetrahedral oligonucleotide nanoparticles. (c) Folic acid (FA) density on the oligonucleotide nanoparticle affects the GFP gene silencing efficiency of the particle. LF, Lipofectamine RNAiMAX formulated with siGFP (siRNA of GFP). 0, 1, 2, 3, or 6 FA represent oligonucleotide nanoparticles with same siGFP concentration and varied number of folic acid. *P < 0.003, **P < 0.001 compared with control (siGFP only). NS, not significant. Adapted with permission.[74] Copyright 2012, Springer Nature.