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. Author manuscript; available in PMC: 2021 Jun 22.
Published in final edited form as: Adv Ther (Weinh). 2020 Feb 13;3(3):1900206. doi: 10.1002/adtp.201900206

Figure 9.

Figure 9.

Schematic illustration of rolling circle amplification-assisted DNA assembly for CpG oligodeoxynucleotide (CpG ODN) and anti-PD-1 antibody (aPD1) delivery. (a) CpG-sequence containing DNA assembly was loaded with aPD1 and caged restriction enzyme. Under inflammation condition, proteolytic enzyme degrades triglycerol monostearate (TGMS) and releases the restriction enzyme, triggering the fragmentation of DNA assembly. As a result, CpG ODN and aPD1 are released at the inflammation site. (b) With aPD1 for PD 1 blockade, released CpG ODN activates dendritic cells (DCs) to drive T cell response, enhancing the immune response against cancer cells. Adapted with permission.[81] Copyright 2016, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.