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. 2021 Jun 22;111(4):406–415. doi: 10.1007/s00392-021-01892-1

Table 4.

Changes in heart failure medication and lipid lowering therapy during follow-up

Baseline Month 4 Month 8 Month 12 P for trend*
N = 12 N = 12 N = 11 N = 12
ACEi /ARB, n (%) 6 (50) 5 (42) 6 (55) 4 (33) 1.0
ARNI, n (%) 5 (42) 7 (58) 5 (45) 8 (67) 0.19
Betablocker, n (%) 10 (83) 10 (83) 9 (82) 11 (92) 1.0
MRA, n (%) 8 (67) 8 (67) 7 (64) 8 (67) N.A
Ivabradine, n (%) 2 (17) 3 (25) 3 (27) 3 (25) 1.0
Diuretics, n (%) 6 (50) 7 (58) 5 (45) 6 (50) 0.56
Lipid lowering drug, n (%) 5 (42) 5 (42) 5 (45) 5 (42) N.A
OMT, n (%) 10 (83) 12 (100) 11 (100) 12 (100) 0.35

*Page’s linear trend test. N.A. Page test not applicable

ACEi/ARB, angiotensin converting enzyme inhibitor or angiotensin receptor blocker; ARNI, angiotensin receptor neprilysin inhibitor, MRA mineralocorticoid receptor blocker, OMT optimal medical therapy