Table 5.

Factors associated with severity in C. d. ruruima envenomings reported in the state of Roraima, northern Brazilian Amazon, from 2010 to 2019.

Severity#	RR	95% CI	P	aRR	95%CI	P
Underdosage	1.69	1.06-2.69	0.026	1.91	1.18-3.09	0.008
Time to care >6 hours	1.79	1.11-2.91	0.018	1.85	1.14-2.99	0.013
Amerindian ethnicity	1.45	0.85-2.48	0.166	1.84	1.04-3.26	0.036
Site of the bite (lower limbs)	0.51	0.30-0.87	0.014	0.44	0.26-0.76	0.003
Schooling (years)
Illiterate	1
≤4	0.81	0.30-2.19	0.687
5-8	1.03	0.37-2.87	0.950
>8	0.94	0.34-2.57	0.913
Gender (Women)	0.67	0.35-1.27	0.227
Work-related	1.35	0.69-2.66	0.371
Rural zone	1.37	0.46-4.07	0.568
Age (years)
≤15	1
16-45	0.97	0.55-1.67	0.906
46-60	1.08	0.50-2.33	0.842
>60	1.09	0.44-2.72	0.844

Proportions of severe cases and deaths were compared by Chi-square test (corrected by Fisher’s test if necessary); differences were considered statistically significant for p<0.05. The crude Relative Risk (RR) with its respective 95% Confidence Interval (95% CI) was determined considering severity and death as the dependent variables. Logistic regression was used for the multivariable analyses, and the adjusted RR with 95% CI were also calculated. All variables associated with the outcomes at a significance level of p<0.20 in the univariable analysis were included in the multivariable analysis. Statistical significance was considered if p<0.05 in the Hosmer-Lemeshow goodness-of-fit test. aRR, Adjusted Relative Risk.

Bolded values represent variables significantly associated to severity.