Table 1. Gene Ontology of Runx1 Regulated Genes.
This table shows the top 5 gene ontology categories from the S2 Table, based on the fold enrichment for genes down-regulated in Runx1KO cells (top) or down-regulated in Runx1KO cells (bottom).
| Runx1KO Down-regulated Gene Biological Process Gene Ontology | GO number | Fold Enrichment | p-value | FDR |
| Transforming growth factor beta receptor complex assembly | 7181 | 23.73 | 1.20x10-03 | 3.39x10-02 |
| Condensed mesenchymal cell proliferation | 72137 | 17.8 | 2.04x10-03 | 4.99x10-02 |
| Regulation of serotonin uptake | 51611 | 17.8 | 2.04x10-03 | 4.98x10-02 |
| Chemoattraction of axon | 61642 | 17.8 | 2.04x10-03 | 4.98x10-02 |
| Negative regulation of synapse assembly | 51964 | 15.82 | 4.59x10-04 | 1.63x10-02 |
| Runx1KO Up-regulated Gene Biological Process Gene Ontology | GO number | Fold Enrichment | p-value | FDR |
| Positive regulation of cGMP-mediated signaling | 10753 | 9.3 | 2.32x10-04 | 2.16x10-02 |
| Gamma-delta T cell activation | 46629 | 8.45 | 3.40x10-04 | 2.85x10-02 |
| Regulation of ribonuclease activity | 60700 | 8.26 | 3.86x10-05 | 5.38x10-03 |
| Positive regulation of epidermal growth factor-activated receptor activity | 45741 | 7.15 | 6.72x10-04 | 4.72x10-02 |
| Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent | 2486 | 6.38 | 5.83x10-07 | 2.30x10-04 |