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Several aspects of melatonin’s effect on exosome biogenesis and secretion are still unknown. Melatonin can enter the cells via membrane-bound receptors and passive diffusion. It is logical to state that melatonin can be secret via the exosomes to the extracellular niche. Whether melatonin directly or indirectly influences exosome biogenesis, trafficking and abscission need further investigation.
