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. 2021 Jun 8;11:642134. doi: 10.3389/fonc.2021.642134

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Copyright © 2021 Jiang, Wang, Mu, Ma, Wang, Lv, Zhang, Xu, Wang, Li, Han, Yang, Wang, Zeng, Jin, Xue, Yin, Sun, Hua and Cai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NHWD-870 reverses oncogenic signature in osteosarcoma. (A) Heatmap of differentially expressed genes (log2FC<-1, log2FC<-1, and adjusted p value < 0.01) in 143B and HOS cells treated with NHWD-870 (1 μM for 24 hours) versus DMSO. (B) Volcano plot showing the differentially expressed genes (DEGs) between the NHWD-870-treated and DMSO groups. (adjusted p value < 0.01). (C) Venn diagram of the significantly downregulated transcripts in 143B and HOS osteosarcoma cells treated with 1 μM NHWD-870 for 24 hours. (D) GO analyses of the 904 overlapping significantly downregulated genes. The top 10 hits in each category were presented. (E) KEGG analyses of the 904 overlapping significantly downregulated genes. Top 10 hits in each category were presented. (F, G) GSEA showing enrichment of gene sets in DMSO- or NHWD-870-treated 143B cell lines.