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. 2021 Jun 8;11:642134. doi: 10.3389/fonc.2021.642134

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Copyright © 2021 Jiang, Wang, Mu, Ma, Wang, Lv, Zhang, Xu, Wang, Li, Han, Yang, Wang, Zeng, Jin, Xue, Yin, Sun, Hua and Cai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NHWD-870 sensitizes osteosarcoma cells to chemosensitivity by repressing GP130. (A) The expression level of GP130 in chemosensitive and chemoresistance patients was detected using immunohistochemistry. Scale bar = 50 μm. (B) The expression level of GP130 in chemosensitive (U2OS) and chemoresistance (U2OSR) osteosarcoma cell lines was detected using western blotting. (C) 143B cells were transfected with GP130 siRNA for 72 hours. GP130, p-STAT3 Y705, STAT3 and GAPDH were assessed by western blot. (D) Dose-response curve of the 143B scramble and 143B GP130 siRNA cell lines. Data are mean ± SEM. (****P < 0.0001). (E) Cells were treated with NHWD-870 and cisplatin individually or in combination at the indicated concentrations for 72 hours, and cell viability was assessed with a CCK8 assay. Data are shown as mean ± SD. (****P < 0.0001).