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. 2021 Jun 8;11:642134. doi: 10.3389/fonc.2021.642134

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Copyright © 2021 Jiang, Wang, Mu, Ma, Wang, Lv, Zhang, Xu, Wang, Li, Han, Yang, Wang, Zeng, Jin, Xue, Yin, Sun, Hua and Cai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NHWD-870 inhibits tumor-induced osteolysis by inhibiting the differentiation and maturation of osteoclast precursor. (A) The effect of NHWD-870 on inhibiting tumor-induced osteolysis in vivo in each group was detected by micro-CT. Scale bar = 1 mm. (B) Relative parameters of the bone microstructure in each group. (**P < 0.01; and ***P < 0.001, and ****P < 0.0001). (C) The number and distribution of osteoclasts at the tumor-to-normal bone boundary was detected by TRAP. Scale bar = 100 μm. (D) A significant decrease in the number and distribution of osteoclasts demonstrated that NHWD-870 inhibited the differentiation and maturation of osteoclasts, preventing tumor-induced osteolysis. (****P < 0.0001).