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Schematic diagram to describe the action of NHWD-870. STAT3 is phosphorylated by JAKs at tyrosine 705, leading to STAT3 dimerization and nuclear translocation, followed by STAT3-mediated transcription of target genes and cell proliferation. In this process, NHWD-870 disrupted the binding affinity of BRD4 to the promoter region of STAT3 upstream receptor GP130, this weakens the upstream signal transduction, blocking STAT3 dimerization and induced cell apoptosis.
