Figure 13. Diseases and Phenotypes genes (Portal 3).

Examples of in situ hybridization images of genes linked to OMIM- or SFARI-based human neurological and/or psychiatric disorders (sub-portal 3A), or to MGI-based mouse neurological and/or behavioral phenotypes, that show differential expression in various avian brain areas (sub-portal 3B). Gene attributes related to this portal are indicated under each image (vermillion annotations are OMIM- or SFARI-based, blue annotations are MGI-based). (a) Broad expression in telencephalic fields, including pallium, pallial subdivisions, and/or striatum, for genes involved in disorders like seizures or neurodegenerative diseases, or phenotypes disrupting broad learning or locomotor functions. (b) Broad pallial and/or cerebellar expression of genes involved in autism. (c) Differential cerebellar expression for genes involved in cerebellar-related disorders and phenotypes, like ataxias and/or abnormal gait. (d) Discrete expression in nuclei in the pons or hypothalamus for genes involved in disruptions of the serotonergic (left panels) or neuroendocrine (right panels) systems. In (c) and (d), the location of the higher magnification panels in the right or bottom panels are indicated by small rectangles in the left or top panels. Abbreviations for cerebellar cortical layers in (b): gcl, granule cell layer; mcl, molecular layer; pcl, Purkinje cell layer. Scale bars: low-power images = 1 mm; high-power images in (c) and (d) = 200 μm.