Table 7.

Experimental isolation of hybrid dsRNAs host/virus from published datasets. Recently published datasets of the sequences corresponding to experimentally isolated RNA:RNA paired segments from cells infected by SARS-CoV-2 and MERS-CoV (Ziv et al., 2020) were re –analyzed to quantify the host/virus dsRNA fragments compared to internal pairing. This publication reports the wide scale genome catalog of dsRNAs from which one strand has at least a viral origin.

sample	virus/virus interactions		virus/host interactions		other		total count
	count	% of total	count	% of total	count	% of total
a) RNA-RNA interactions spanning the entirety of SARS-CoV-2 gRNA
GSM4676629	315174	85%	23849	6%	29684	8%	368707
GSM4676630	1383051	95%	31519	2%	43506	3%	1458076
GSM4676631	330792	83%	30435	8%	39324	10%	400551
GSM4676632	1594186	92%	45475	3%	88199	5%	1727860
Total	3623203	92%	131278	3%	200713	5%	3955194
b) RNA-RNA interactions spanning the entirety of SARS-CoV-2 sgmRNA
GSM4676637	2421822	73%	522778	16%	372774	11%	3317374
GSM4676638	9676252	85%	817233	7%	934193	8%	11427678
GSM4676639	2835137	70%	669965	17%	531431	13%	4036533
GSM4676640	9648232	81%	970620	8%	1279706	11%	11898558
Total	24581443	80%	2980596	10%	3118104	10%	30680143
c) RNA-RNA interactions spanning the entirety of MERS-CoV gRNA
GSM4676625	577463	66%	137638	16%	161706	18%	876807
GSM4676626	1399538	70%	239390	12%	367489	18%	2006417
GSM4676627	440294	68%	89809	14%	122030	19%	652133
GSM4676628	767696	74%	98421	10%	166175	16%	1032292
Total	3184991	70%	565258	12%	817400	18%	4567649