Table 1.
Baseline characteristics of log NT-proBNP categories
| Low-Low | Low-High | High-Low | High-High | P value | |
|---|---|---|---|---|---|
| Participants, n (%) | 681 (37.1) | 238 (13.0) | 239 (13.0) | 680 (37.0) | |
| Age in years, mean (SD) | 55.0 (7.6) | 59.8 (8.8) | 56.7 (7.8) | 63.5 (9.2) | <0.001 |
| Males, n (%) | 446 (65.5) | 134 (56.3) | 88 (36.8) | 211 (31.0) | <0.001 |
| Race | |||||
| Caucasian American | 233 (34.2) | 91 (38.2) | 124 (51.9) | 360 (52.9) | |
| Black American | 166 (24.4) | 70 (29.4) | 42 (17.6) | 120 (17.7) | <0.001 |
| Hispanic American | 153 (22.5) | 53 (22.3) | 45 (18.8) | 136 (20.0) | |
| Chinese American | 129 (18.9) | 24 (10.1) | 28 (11.7) | 64 (9.4) | |
| BMI, kg/m2, mean (SD) | 27.65 (4.5) | 28.61 (5.2) | 27.75 (5.0) | 27.48 (5.3) | 0.02 |
| SBP, mm Hg, mean (SD) | 117.55 (15.4) | 124.66 (16.6) | 120.87 (22.6) | 126.98 (22.8) | <0.001 |
| DBP, mm Hg, mean (SD) | 72.80 (9.3) | 73.58 (9.1) | 71.27 (11.7) | 69.84 (10.55) | <0.001 |
| HDL cholesterol, mg/dl, mean (SD) | 47.68 (12.8) | 49.00 (14.2) | 53.45 (16.2) | 55.07 (15.6) | <0.001 |
| LDL cholesterol, mg/dl, mean (SD) | 119.76 (29.6) | 120.14 (35.3) | 110.97 (26.8) | 117.0 (31.9) | 0.001 |
| Total cholesterol, mg/dl, mean (SD) | 194.41 (34.6) | 195.84 (39.2) | 189.90 (35.6) | 196.47 (34.5) | 0.09 |
| Lipid lowering medication, n (%) | 87 (12.8) | 45 (18.9) | 35 (14.6) | 91 (13.4) | 0.12 |
| Diabetes mellitus, n (%) | 58 (8.5) | 42 (17.6) | 13 (5.5) | 59 (8.7) | <0.001 |
| Hypertension, n (%) | 169 (24.8) | 93 (39.1) | 86 (36.0) | 305 (44.9) | <0.001 |
| Antihypertensive medication use, n (%) | 141 (20.7) | 82 (34.5) | 75 (31.4) | 245 (36.0) | <0.001 |
| Current smoker, n (%) | 82 (12.0) | 29 (12.2) | 30 (12.6) | 62 (9.1) | 0.25 |
| NT-proBNP, pg/ml, median (IQR) | 15.34 (6.8–27.9) | 28.6 (18.3–37.8) | 66.9 (53.0–85.9) | 99.16 (67.0–149.7) | <0.001 |
| LA maximum volume index, ml/m2, mean (SD) | 28.07 (7.9) | 28.39 (8.7) | 30.23 (8.6) | 31.25 (9.4) | <0.001 |
| LA minimum volume index, ml/m2, mean (SD) | 10.88 (5.0) | 11.37 (5.6) | 11.83 (5.7) | 12.80 (6.5) | <0.001 |
| LA total emptying fraction, %, mean (SD) | 62.93 (11.4) | 61.87 (12.0) | 62.75 (12.1) | 61.06 (11.1) | 0.02 |
| LA passive emptying fraction, %, mean (SD) | 26.67 (9.4) | 26.71 (9.5) | 27.69 (9.4) | 26.16 (8.3) | 0.21 |
| LA active emptying fraction, %, mean (SD) | 49.38 (12.4) | 47.93 (14.0) | 48.24 (14.4) | 47.21 (16.7) | 0.04 |
| LA maximum strain, %, mean (SD) | 36.73 (10.2) | 36.70 (11.6) | 38.74 (12.1) | 37.13 (11.4) | 0.10 |
| LV ejection fraction, %, mean (SD) | 62.09 (5.6) | 62.42 (5.3) | 62.93 (5.6) | 63.25 (5.6) | 0.001 |
| LV mass, g, mean (SD) | 125.36 (27.7) | 125.44 (25.9) | 116.63 (28.7) | 115.32 (29.5) | <0.001 |
| LV end-diastolic volume index, ml/m2, mean (SD) | 71.19 (11.8) | 69.08 (12.6) | 71.18 (10.9) | 69.49 (12.2) | <0.001 |
| LV end-systolic volume index, ml/m2, mean (SD) | 26.93 (5.8) | 25.98 (6.2) | 26.34 (5.5) | 25.60 (6.8) | 0.001 |
Abbreviations: BMI, body mass index; DBP, diastolic blood pressure; HDL, high-density lipoprotein; LA, left atrium; LDL, low-density lipoprotein; LV, left ventricle; SBP, systolic blood pressure.