Table 2.
Cross-sectional association between log NT-proBNP and LA parameters at 10 years
| Univariate | Multivariable | R 2 | |||
|---|---|---|---|---|---|
| Log NT-proBNP | Log NT-proBNP | Log NT-proBNP | Log NT-proBNP | ||
| ≤4.2 pg/ml | >4.2 pg/ml | ≤4.2 pg/ml | >4.2 pg/ml | ||
| LA maximum volume index, ml/m2 | 1.23* | 3.61* | 0.56 | 3.36* | 0.33 |
| (0.18, 2.28) | (2.86, 4.36) | (−0.42, 1.53) | (2.64, 4.09) | ||
| LA minimum volume index, ml/m2 | −0.04 | 3.76* | 0.06 | 3.30* | 0.30 |
| (−0.76, 0.68) | (3.24, 4.27) | (−0.64, 0.77) | (2.78, 3.82) | ||
| LA total emptying fraction, % | 1.10* | −4.75* | −0.12 | −3.94* | 0.30 |
| (0.05, 2.15) | (−5.51, −4.00) | (−1.12, 0.87) | (−4.68, −3.20) | ||
| LA passive emptying fraction, % | 0.04 | −2.50* | −0.21 | −1.08* | 0.36 |
| (−0.76, 0.84) | (−3.07, −1.92) | (−0.92, 0.50) | (−1.61, −0.55) | ||
| LA active emptying fraction, % | 1.30* | −4.07* | −0.07 | −4.22* | 0.20 |
| (0.18,2.43) | (−4.89, −3.26) | (−1.19, 1.06) | (−5.06, −3.39) | ||
| LA maximum strain, % | 1.90* | −3.72* | −0.06 | −3.02* | 0.27 |
| (0.53, 3.27) | (−4.70, −2.74) | (−1.36, 1.24) | (−3.99, −2.06) | ||
Coefficients and 95% confidence intervals (in brackets) for multivariable linear spline regression models to assess the cross-sectional associations at 10-year follow-up. The inflection point was chosen at log NT-proBNP value of 4.2 pg/ml. Multivariable model is adjusted for age, gender and race/ethnicity, systolic blood pressure, diastolic blood pressure, hypertension, antihypertensive medications, HDL cholesterol, LDL cholesterol, total cholesterol, lipid lowering medications, BMI, diabetes mellitus, smoking status, LV ejection fraction, LV mass, and mass–volume ratio. Abbreviations: BMI, body mass index; HDL, high-density lipoprotein; LA, left atrium; LDL, low-density lipoprotein; LV, left ventricle.
*If P value <0.05.