Table 1.
Brain tissue volumes, demographic and clinical characteristics of patients and healthy controls
|
Patients
(n = 42) |
Healthy controls
(n = 16) |
P-values | |
|---|---|---|---|
| Age, years | 33.1 ± 1.03 | 33.3 ± 1.7 | 0.89a |
| Sex, female: male (% female) | 23:19 (55) | 9:7 (56) | 0.92b |
| Syndrome, n (%) | |||
| Optic neuritis | 35 (83) | – | |
| Myelitis | 2 (5) | – | |
| Brainstem syndrome | 2 (5) | – | |
| Supratentorial syndrome | 2 (5) | – | |
| Multifocal | 1 (2) | ||
| Steroids, n (%) | 10 (24) | – | – |
| Months from onset | 2.1 ± 1.2 | ||
| Grey matter volume, ml | 670.2 ± 52 | 670.8 ± 66.2 | 0.97c |
| White matter volume, ml | 454.7 ± 39.6 | 467 ± 50.6 | 0.33c |
| Brain parenchymal fraction | 0.76 ± 0.009 | 0.76 ± 0.02 | 0.64c |
| White matter T2-hyperintense lesion volume, ml, median (range) | 3.2 (0–42.2) | – | |
| White matter T1-hypointense lesion volume, ml, median (range) | 0.3 (0–6.2) | – | |
| Spinal cord lesions, median (range) | 0 (0–7) |
Data are presented as mean ± standard deviation, unless otherwise indicated.
a
Two-sample t-tests.
b
Pearson's chi-squared test.
c
Linear regression model correcting for age and sex.