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Soon after pharynx loss, stem cells recognize the pharynx is missing and target regeneration toward the pharynx by selectively inducing division of existing FoxA-expressing stem cells (red), or expression of FoxA in division-competent stem cells, within 1–2 days. This division drives an ERK-dependent increase in pharynx progenitors 3 days after pharynx loss, which is required for pharynx regeneration.
