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. 2021 Jun 15;2021:6644238. doi: 10.1155/2021/6644238

Figure 1.

Figure 1

SS-31 reduces CS-induced increases in inflammatory cell numbers and cytokine infiltration in mouse lung. (a–f) Total cell (a), neutrophil (b), and macrophage (c) counts and IL-6 (d), TNF-α (e), and MMP9 (f) levels in mouse BALF (control: n = 7, CS: n = 5, SS-31 (L)+CS: n = 8, SS-31 (H)+CS: n = 5). ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001 vs. control; #P < 0.05, ##P < 0.01, and ####P < 0.0001 vs. CS; &&P < 0.01, &&&P < 0.001, and SS-31 (L)+CS vs. SS-31 (H)+CS. Abbreviations: BALF: bronchoalveolar lavage fluid; CS: cigarette smoke; SS-31 (H): high-dose SS-31 (5 mg/kg); SS-31 (L): low-dose SS-31 (2.5 mg/kg).