Table 2.
Rate ratios for severe COVID-19 in those not resident in care homes
| Univariate | Multivariable | |||||
|---|---|---|---|---|---|---|
| Controls (86,902) | Cases (7217) | Rate ratio (95% CI) | p-value | Rate ratio (95% CI) | p-value | |
| No risk condition | 45,354 (52%) | 1897 (26%) | . | . | ||
| Moderate risk condition | 33,909 (39%) | 3702 (51%) | 3.20 (3.01, 3.41) | <0.001 | 2.67 (2.50, 2.85) | <0.001 |
| Shielding eligibility category | ||||||
| Solid organ transplant | 112 (0%) | 59 (1%) | 13.4 (9.6, 18.8) | <0.001 | 7.0 (4.6, 10.4) | <0.001 |
| Specific cancers | 907 (1%) | 240 (3%) | 7.9 (6.8, 9.3) | <0.001 | 3.47 (2.87, 4.19) | <0.001 |
| Severe respiratory | 3751 (4%) | 733 (10%) | 5.8 (5.2, 6.4) | <0.001 | 4.32 (3.87, 4.83) | <0.001 |
| Rare diseases | 341 (0%) | 69 (1%) | 7.0 (5.3, 9.3) | <0.001 | 4.68 (3.37, 6.49) | <0.001 |
| On immunosuppressants | 742 (1%) | 126 (2%) | 4.61 (3.76, 5.65) | <0.001 | 3.26 (2.59, 4.10) | <0.001 |
| Additional conditions | 1786 (2%) | 391 (5%) | 6.6 (5.8, 7.5) | <0.001 | 4.31 (3.72, 5.00) | <0.001 |
| At least one child under 5 | 1759 (2%) | 150 (2%) | 0.87 (0.73, 1.04) | 0.1 | 0.73 (0.60, 0.89) | 0.002 |
| Number of school age children in household | ||||||
| 0 school age | 80,885 (93%) | 6685 (93%) | . | . | ||
| 1 school age | 1749 (2%) | 93 (1%) | 0.54 (0.43, 0.67) | <0.001 | 0.76 (0.60, 0.96) | 0.02 |
| 2 or more | 4268 (5%) | 439 (6%) | 1.06 (0.95, 1.19) | 0.3 | 0.71 (0.62, 0.80) | <0.001 |
| Number of adults in household | ||||||
| 1 adult | 62,011 (72%) | 4259 (59%) | . | . | ||
| 2 adults | 19,190 (22%) | 1951 (27%) | 1.57 (1.48, 1.67) | <0.001 | 1.80 (1.68, 1.92) | <0.001 |
| 3 to 4 | 4611 (5%) | 769 (11%) | 2.50 (2.28, 2.74) | <0.001 | 3.19 (2.87, 3.54) | <0.001 |
| 5 to 9 | 326 (0%) | 85 (1%) | 3.98 (3.10, 5.11) | <0.001 | 5.8 (4.3, 7.7) | <0.001 |
| 10 or more | 247 (0%) | 102 (1%) | 10.6 (7.6, 14.6) | <0.001 | 11.4 (8.0, 16.2) | <0.001 |
| SIMD quintile | ||||||
| 1 - most deprived | 21,388 (25%) | 2162 (30%) | . | . | ||
| 2 | 19,072 (22%) | 1761 (24%) | 0.91 (0.85, 0.98) | 0.01 | 0.95 (0.88, 1.03) | 0.3 |
| 3 | 15,399 (18%) | 1264 (18%) | 0.76 (0.70, 0.82) | <0.001 | 0.84 (0.76, 0.92) | <0.001 |
| 4 | 14,870 (17%) | 1079 (15%) | 0.65 (0.59, 0.70) | <0.001 | 0.72 (0.65, 0.79) | <0.001 |
| 5 - least deprived | 16,084 (19%) | 944 (13%) | 0.53 (0.48, 0.58) | <0.001 | 0.60 (0.53, 0.66) | <0.001 |
| Occupation | ||||||
| Other / undetermined | 84,672 (98%) | 6962 (97%) | . | . | ||
| Teacher | 336 (0%) | 11 (0%) | 0.35 (0.19, 0.64) | <0.001 | 0.42 (0.22, 0.81) | 0.01 |
| Health care, not PF / undetermined | 826 (1%) | 87 (1%) | 1.18 (0.94, 1.47) | 0.2 | 1.20 (0.94, 1.53) | 0.2 |
| Health care PF | 846 (1%) | 145 (2%) | 1.80 (1.50, 2.16) | <0.001 | 1.86 (1.52, 2.27) | <0.001 |
| Recent hospital visit/stay | 3565 (4%) | 2415 (33%) | 12.3 (11.5, 13.2) | <0.001 | 10.2 (9.5, 11.0) | <0.001 |
Severe COVID-19 is defined by entry to critical care or fatal outcome
Percentages are column percentages for each variable
PF, patient-facing
Rate ratios are from conditional logistic regression models with cases and controls matched for age, sex and general care practice
Univariate rate ratios are for models with a single covariate
Multivariable rate ratios are for a model including all covariates shown in the table