Table 3.

Rate ratios for severe COVID-19 associated with risk conditions (with severe respiratory disease as reference category) in those eligible for shielding and not resident in care homes

			Univariate		Multivariable
	Controls (7808)	Cases (1640)	Rate ratio (95% CI)	p-value	Rate ratio (95% CI)	p-value
Shielding eligibility category
Severe respiratory	3834 (49%)	744 (45%)		.		.
Solid organ transplant	112 (1%)	60 (4%)	1.58 (0.90, 2.77)	0.1	1.36 (0.70, 2.63)	0.4
Specific cancers	925 (12%)	240 (15%)	1.28 (0.98, 1.66)	0.07	0.88 (0.64, 1.21)	0.4
Rare diseases	348 (4%)	72 (4%)	1.18 (0.75, 1.84)	0.5	1.14 (0.68, 1.91)	0.6
On immunosuppressants	759 (10%)	129 (8%)	0.74 (0.53, 1.03)	0.07	0.82 (0.56, 1.20)	0.3
Additional conditions	1830 (23%)	395 (24%)	1.19 (0.95, 1.49)	0.1	1.00 (0.77, 1.31)	1
At least one child under 5	66 (1%)	27 (2%)	0.80 (0.32, 2.02)	0.6	0.45 (0.15, 1.31)	0.1
School-age children in household
0 school age	7537 (97%)	1545 (94%)		.		.
1 school age	82 (1%)	19 (1%)	0.36 (0.13, 0.99)	0.05	0.84 (0.29, 2.45)	0.7
2 or more	189 (2%)	76 (5%)	1.03 (0.60, 1.76)	0.9	0.74 (0.40, 1.37)	0.3
Adults in household
1 adult	5811 (75%)	1010 (62%)		.		.
2 adults	1647 (21%)	458 (28%)	1.60 (1.30, 1.97)	<0.001	1.74 (1.37, 2.21)	<0.001
3 or more	339 (4%)	167 (10%)	2.15 (1.51, 3.07)	<0.001	2.52 (1.66, 3.82)	<0.001
SIMD quintile (integer)	2 (1–4)	2 (1–4)	0.97 (0.91, 1.05)	0.5	0.98 (0.90, 1.06)	0.6
Recent hospital visit/stay	840 (11%)	739 (45%)	5.8 (4.6, 7.4)	<0.001	6.0 (4.7, 7.7)	<0.001

Severe COVID-19 is defined by entry to critical care or fatal outcome

Percentages are column percentages for each variable

Rate ratios are from conditional logistic regression models matched for age, sex and general practice

Univariate rate ratios are for models with a single covariate

Multivariable rate ratios are for a model including all covariates shown in the table