Table 1.
Non-SGTF (n=80 494) | SGTF (n=117 926) | Full cohort (n=198 420) | ||
---|---|---|---|---|
Admitted to CCU | 271 (0·3%) | 565 (0·5%) | 836 (0·4%) | |
Deaths within 28 days | 334 (0·4%) | 565 (0·5%) | 899 (0·5%) | |
Sex | ||||
Female | 42 976 (53·4%) | 61 679 (52·3%) | 104 655 (52·7%) | |
Male | 37 518 (46·6%) | 56 247 (47·7%) | 93 765 (47·3%) | |
Mean age, years | 38·0 (18·1) | 37·4 (17·6) | 37·7 (17·8) | |
Age categories, years | ||||
18–29 | 29 122 (36·2%) | 42 000 (35·6%) | 71 122 (35·8%) | |
30–39 | 15 412 (19·1%) | 24 012 (20·4%) | 39 424 (19·9%) | |
40–49 | 13 255 (16·5%) | 20 622 (17·5%) | 33 877 (17·1%) | |
50–59 | 12 604 (15·7%) | 18 342 (15·6%) | 30 946 (15·6%) | |
60–69 | 6318 (7·8%) | 8662 (7·3%) | 14 980 (7·5%) | |
70–79 | 2510 (3·1%) | 2994 (2·5%) | 5504 (2·8%) | |
80–89 | 1022 (1·3%) | 1073 (0·9%) | 2095 (1·1%) | |
90–99 | 251 (0·3%) | 221 (0·2%) | 472 (0·2%) | |
Ethnicity | ||||
White | 49 016 (60·9%) | 68 907 (58·4%) | 117 923 (59·4%) | |
Indian | 3046 (3·8%) | 4900 (4·2%) | 7946 (4·0%) | |
Pakistani | 4045 (5·0%) | 4323 (3·7%) | 8368 (4·2%) | |
Bangladeshi | 2008 (2·5%) | 3549 (3·0%) | 5557 (2·8%) | |
Other Asian | 1526 (1·9%) | 2958 (2·5%) | 4484 (2·3%) | |
Caribbean | 400 (0·5%) | 1339 (1·1%) | 1739 (0·9%) | |
Black African | 1295 (1·6%) | 2803 (2·4%) | 4098 (2·1%) | |
Chinese | 159 (0·2%) | 373 (0·3%) | 532 (0·3%) | |
Other ethnic group | 2647 (3·3%) | 5162 (4·4%) | 7809 (3·9%) | |
Not recorded | 16 352 (20·3%) | 23 612 (20·0%) | 39 964 (20·1%) | |
Date of positive test | ||||
Nov 1–14, 2020 | 26 160 (32·5%) | 1784 (1·5%) | 27 944 (14·1%) | |
Nov 15–28, 2020 | 16 509 (20·5%) | 2879 (2·4%) | 19 388 (9·8%) | |
Nov 29 to Dec 12, 2020 | 10 990 (13·7%) | 7704 (6·5%) | 18 694 (9·4%) | |
Dec 13–26, 2020 | 10 847 (13·5%) | 23 700 (20·1%) | 34 547 (17·4%) | |
Dec 27, 2020, to Jan 10, 2021 | 11 368 (14·1%) | 46 921 (39·8%) | 58 289 (29·4%) | |
Jan 11–26, 2021 | 4620 (5·7%) | 34 938 (29·6%) | 39 558 (19·9%) | |
Household size | ||||
1 person | 21 580 (26·8%) | 30 432 (25·8%) | 52 012 (26·2%) | |
2 people | 16 618 (20·6%) | 23 358 (19·8%) | 39 976 (20·1%) | |
3–5 people | 36 192 (45·0%) | 55 186 (46·8%) | 91 378 (46·1%) | |
≥6 people | 6104 (7·6%) | 8950 (7·6%) | 15 054 (7·6%) | |
House type | ||||
Neither | 80 219 (99·7%) | 117 549 (99·7%) | 197 768 (99·7%) | |
Care home | 226 (0·3%) | 271 (0·2%) | 497 (0·3%) | |
Homeless | 49 (0·1%) | 106 (0·1%) | 155 (0·1%) | |
BMI | ||||
<25 | 43 759 (54·4%) | 64 816 (55·0%) | 108 575 (54·7%) | |
25 to <30 | 10 654 (13·2%) | 14 706 (12·5%) | 25 360 (12·8%) | |
30 to <40 | 4528 (5·6%) | 6007 (5·1%) | 10 535 (5·3%) | |
≥40 | 2540 (3·2%) | 3151 (2·7%) | 5691 (2·9%) | |
Not recorded | 19 013 (23·6%) | 29 246 (24·8%) | 48 259 (24·3%) | |
Smoking status | ||||
Non-smoker | 46 182 (57·4%) | 65 447 (55·5%) | 111 629 (56·3%) | |
Ex-smoker | 14 262 (17·7%) | 20 642 (17·5%) | 34 904 (17·6%) | |
Light smoker | 6455 (8·0%) | 11 276 (9·6%) | 17 731 (8·9%) | |
Moderate smoker | 1222 (1·5%) | 2050 (1·7%) | 3272 (1·6%) | |
Heavy smoker | 429 (0·5%) | 702 (0·6%) | 1131 (0·6%) | |
Not recorded | 11 944 (14·8%) | 17 809 (15·1%) | 29 753 (15·0%) | |
Geographical region in England | ||||
East Midlands | 1529 (1·9%) | 1305 (1·1%) | 2834 (1·4%) | |
East of England | 1428 (1·8%) | 3912 (3·3%) | 5340 (2·7%) | |
London | 13 302 (16·5%) | 37 342 (31·7%) | 50 644 (25·5%) | |
North East | 4066 (5·1%) | 2194 (1·9%) | 6260 (3·2%) | |
North West | 26 808 (33·3%) | 22 416 (19·0%) | 49 224 (24·8%) | |
South Central | 6754 (8·4%) | 15 073 (12·8%) | 21 827 (11·0%) | |
South East | 3609 (4·5%) | 17 945 (15·2%) | 21 554 (10·9%) | |
South West | 3966 (4·9%) | 3893 (3·3%) | 7859 (4·0%) | |
West Midlands | 14 235 (17·7%) | 12 140 (10·3%) | 26 375 (13·3%) | |
Yorkshire and Humber | 4797 (6·0%) | 1706 (1·4%) | 6503 (3·3%) | |
Deprivation quintile | ||||
1 (least deprived) | 17 606 (21·9%) | 22 650 (19·2%) | 40 256 (20·3%) | |
2 | 17 507 (21·7%) | 25 312 (21·5%) | 42 819 (21·6%) | |
3 | 17 128 (21·3%) | 25 327 (21·5%) | 42 455 (21·4%) | |
4 | 16 054 (19·9%) | 23 521 (19·9%) | 39 575 (19·9%) | |
5 (most deprived) | 11 622 (14·4%) | 20 321 (17·2%) | 31 943 (16·1%) | |
Not recorded | 577 (0·7%) | 795 (0·7%) | 1372 (0·7%) | |
Comorbidities | ||||
Asthma | 12 551 (15·6%) | 17 241 (14·6%) | 29 792 (15·0%) | |
COPD | 875 (1·1%) | 998 (0·8%) | 1873 (0·9%) | |
Diabetes type 1 | 440 (0·5%) | 618 (0·5%) | 1058 (0·5%) | |
Diabetes type 2 | 4101 (5·1%) | 5188 (4·4%) | 9289 (4·7%) | |
Hypertension | 8473 (10·5%) | 11 163 (9·5%) | 19 636 (9·9%) | |
Parkinson | 64 (0·1%) | 82 (0·1%) | 146 (0·1%) | |
Epilepsy | 872 (1·1%) | 1278 (1·1%) | 2150 (1·1%) | |
Cerebral palsy | 73 (0·1%) | 107 (0·1%) | 180 (0·1%) | |
Motor neuron disease | <5 (<0·1%) | 5 (<0·1%) | 8 (<0·1%) | |
Huntington's disease | <5 (<0·1%) | 5 (<0·1%) | 6 (<0·1%) | |
Multiple sclerosis | 115 (0·1%) | 152 (0·1%) | 267 (0·1%) | |
Myasthenia | 20 (<0·1%) | 28 (<0·1%) | 48 (<0·1%) | |
Down syndrome | 30 (<0·1%) | 51 (<0·1%) | 81 (<0·1%) | |
Learning disabilities excluding Down | 1343 (1·7%) | 1798 (1·5%) | 3141 (1·6%) |
Data are n (%) or mean (SD). Mortality data is updated up to Feb 23, 2021, and CCU admission data up to Feb 7, 2021. Values lower than five are not disclosed for protection of patient confidentiality. BMI=body-mass index. CCU=critical care unit. COPD=chronic obstructive pulmonary disease. SGTF=S-gene molecular diagnostic assay failure.