Table 2.
Demographic characteristics and medical characteristics and indicators of acute severity observed for patients who were critically ill and tested positive in the community between Nov 1, 2020, and Feb 7, 2021 (critical care cohort), by lineage
| Non-SGTF (n=1587) | SGTF (n=2685) | Full cohort (n=4272) | ||
|---|---|---|---|---|
| Mean age, years | 59·2 (12·8) | 58·1 (12·2) | 58·5 (12·5) | |
| Sex | ||||
| Female | 521 (32·8%) | 908 (33·8%) | 1429 (33·5%) | |
| Male | 1066 (67·2%) | 1777 (66·2%) | 2843 (66·5%) | |
| Ethnicity | ||||
| White | 1149 (72·4%) | 1754 (65·3%) | 2903 (68·0%) | |
| Indian | 63 (4·0%) | 106 (3·9%) | 169 (4·0%) | |
| Pakistani | 96 (6·0%) | 128 (4·8%) | 224 (5·2%) | |
| Bangladeshi | 23 (1·4%) | 51 (1·9%) | 74 (1·7%) | |
| Other Asian | 62 (3·9%) | 120 (4·5%) | 182 (4·3%) | |
| Caribbean | 13 (0·8%) | 35 (1·3%) | 48 (1·1%) | |
| Black African | 13 (0·8%) | 47 (1·8%) | 60 (1·4%) | |
| Chinese | 7 (0·4%) | 10 (0·4%) | 17 (0·4%) | |
| Other ethnic group | 63 (4·0%) | 141 (5·3%) | 204 (4·8%) | |
| Not recorded | 98 (6·2%) | 293 (10·9%) | 391 (9·2%) | |
| Previous length of hospital stay, days | ||||
| Mean | 2·5 (12·9; n=1580) | 3·0 (15·9; n=2640) | 2·8 (14·9; n=4220) | |
| Median | 1 (0–3; n=1580) | 1 (0–3; n=2640) | 1 (0–3; n=4220) | |
| Dependency before admission to acute hospital care | ||||
| Able to live without assistance in daily activities | 1378 (86·8%) | 2189 (81·5%) | 3567 (83·5%) | |
| Some assistance in daily activities | 133 (8·4%) | 161 (6·0%) | 294 (6·9%) | |
| Total assistance with all daily activities | <5 (<0·1%) | <5 (<0·1%) | 9 (0·2%) | |
| Not recorded | 72 (4·5%) | 330 (12·3%) | 402 (9·4%) | |
| Severe comorbidities | ||||
| Cardiovascular | <5 (<0·1%) | >10 | 17 (0·4%) | |
| Respiratory | 11 (0·7%) | 21 (0·8%) | 32 (0·7%) | |
| Renal* | 9 (0·6%) | 10 (0·4%) | 19 (0·4%) | |
| Liver | >10 | <5 (<0·1%) | 9 (0·2%) | |
| Metastatic disease | 5 (0·3%) | 5 (0·2%) | 10 (0·2%) | |
| Haematological malignancy | 13 (0·8%) | 10 (0·4%) | 23 (0·5%) | |
| Immunocompromised | 32 (2·0%) | 41 (1·5%) | 73 (1·7%) | |
| BMI | ||||
| <25 | 376 (23·7%) | 851 (31·7%) | 1227 (28·7%) | |
| 25 to <30 | 439 (27·7%) | 649 (24·2%) | 1088 (25·5%) | |
| 30 to <40 | 587 (37·0%) | 870 (32·4%) | 1457 (34·1%) | |
| ≥40 | 185 (11·7%) | 315 (11·7%) | 500 (11·7%) | |
| CPR within preceding 21 h | ||||
| In the community | 12 (0·8%) | 8 (0·3%) | 20 (0·5%) | |
| In the hospital | 10 (0·6%) | 20 (0·7%) | 30 (0·7%) | |
| No | 1526 (96·2%) | 2469 (92·0%) | 3995 (93·5%) | |
| Not recorded | 39 (2·5%) | 188 (7·0%) | 227 (5·3%) | |
| Currently or recently pregnant | ||||
| Currently pregnant | 7 (0·4%) | 17 (0·6%) | 24 (0·6%) | |
| Recently pregnant (within 6 weeks) | 5 (0·3%) | 19 (0·7%) | 24 (0·6%) | |
| Not known to be pregnant | 1575 (99·2%) | 2649 (98·7%) | 4224 (98·9%) | |
| Invasively ventilated within first 24 h | ||||
| No | 1131 (71·3%) | 1469 (54·7%) | 2600 (60·9%) | |
| Yes | 372 (23·4%) | 724 (27·0%) | 1096 (25·7%) | |
| Not recorded | 84 (5·3%) | 492 (18·3%) | 576 (13·5%) | |
| APACHE II score | ||||
| Mean | 13·9 (5·1; n=1527) | 13·0 (4·9; n=2292) | 13·3 (5·0; n=3819) | |
| Median | 13 (11–16; n=1527) | 13 (10–16; n=2292) | 13 (10–16; n=3819) | |
| PaO2/FiO2 ratio median | 13·2 (10·0–18·2; n=1416) | 13·6 (9·8–18·0; n=2056) | 13·3 (9·8–18·2; n=3472) | |
| PaO2/FiO2 ratio value | ||||
| <13·3 kPa (<100 mm Hg) | 718 (45·2%) | 1022 (38·1%) | 1740 (40·7%) | |
| 13·3–26·6 kPa (100–200 mm Hg) | 585 (36·9%) | 873 (32·5%) | 1458 (34·1%) | |
| >26·6 kPa (>200 mm Hg) | 113 (7·1%) | 161 (6·0%) | 274 (6·4%) | |
| Not recorded | 718 (45·2%) | 1022 (38·1%) | 1740 (40·7%) | |
| FiO2 [N = 1416/2056] median | 0·60 (0·45–0·75; n=1416) | 0·60 (0·45–0·80; n=2056) | 0·60 (0·45–0·80; n=3472) | |
Data are n (%), mean (SD), or median (IQR). Values lower than five and those denoted as “>10” are not disclosed for protection of patient confidentiality. APACHE II=Acute Physiology And Chronic Health Evaluation II. BMI=body-mass index. CPR=cardiopulmonary resuscitation. FiO2=fractional inspired oxygen. PaO2=arterial oxygen partial pressure. SGTF=S-gene molecular diagnostic assay failure.
*
Chronic, irreversible renal disease and being dialysis-dependent before critical care unit admission.