Table 2. Antagonistic activity of ONO-5430514.

	ONO-5430514
	(µM)	%Inhibition		AV	IC50
S1P2/EDG-5	0.0025	39	37	38	0.0057
	0.008	53	58	56
	0.025	74	69	71
	0.08	83	83	83
LPA1/EDG-2	0.025	−4	4	0	＞ 0.8
	0.08	−10	−8	−9
	0.25	−10	−5	−8
	0.8	−2	−4	−3
S1P3/EDG−3	0.025	−13	−6	−10	＞ 0.8
	0.08	4	6	5
	0.25	2	13	8
	0.8	−1	4	2
LPA2/EDG−4	0.025	1	−2	0	＞ 0.8
	0.08	8	4	6
	0.25	4	1	2
	0.8	0	−3	−1
	JTE-013
	(µM)	%Inhibition		AV	IC50
S1P2/EDG−5	0.0008	20	10	15	0.0053
	0.0025	35	36	35
	0.008	60	58	59
	0.025	80	79	80
	0.08	85	83	84
	0.25	89	91	90
	0.8	95	96	95
	2.5	100	100	100