Table 3.

AUROC, NRI, and IDI by subgroup.

Variable	11-gene score	SAPS 3	APACHE II
24 h emergency department cutoff
AUROC (95% CI)	0.68 (0.52–0.84)	0.69 (0.54–0.83)	0.72 (0.58–0.85)
NRI (95% CI)		0.45* (0.05–0.84)	0.57** (0.22–0.93)
IDI (95% CI)		0.07* (0.01–0.14)	0.08* (0.01–0.15)
Shock patients
AUROC (95% CI)	0.77 (0.6–0.95)	0.64 (0.43–0.85)	.76 (0.59–0.93)
NRI (95% CI)		0.64* (0.08–1.2)	0.5* (0.003–1)
IDI (95% CI)		0.2** (0.06–0.34)	0.23** (0.08–0.38)
Primary determinant of prognosis is ARDS or MODS
AUROC (95% CI)	0.98 (0.93–1)	0.86 (0.67–1)	0.96 (0.88–1)
NRI (95% CI)		0.93** (0.36–1.5)	0.44 (− 0.11 to 0.99)
IDI (95% CI)		0.76** (0.39–1.12)	0.46* (0–0.92)

Performance as measured by AUROC in predicting 60-day mortality of the 11-gene score, SAPS3, and APACHE II are outlined above. Additionally, the categorical Net-Reclassification (NRI) Index and Integrated Discrimation Improvement (IDI) Index are shown for the comparison of SAPS3 and APACHE II alone vs in combination with the 11-gene score using logistic regression modeling. NRI and IDI values greater than 0 are suggestive of improved prognostic performance with the addition of the 11-gene score.

*P < 0.05.

**P < 0.01.