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. 2021 Jun 22;11:13020. doi: 10.1038/s41598-021-92444-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Adjusted VAF for each of the 4 patients. Parts (A–D) correspond to patients 1–4, respectively. The VAF for each patient has been adjusted to better reflect the percentage of cells in the sample that appear to be from the tumor. VAF is shown on the Y axis with each sampling timepoint for a particular patient shown on the X axis.