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. 2021 Jun 22;12:3825. doi: 10.1038/s41467-021-23755-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Surface mapping of the interaction effect between KL-VS^het and amyloid-PET levels on tau-PET accumulation within 34 left-hemispheric regions of the Desikan–Killiany atlas. Yellow colors indicate higher t-values reflective of a stronger interaction effect (all t-values inverted for illustration purpose; see Supplementary Table 2 for details statistical results). b Thresholded spatial map color-code only regions with a significant (p < 0.01, unadjusted for multiple comparisons) KL-VS^het × amyloid-PET interaction effect. c Surface mapping of median KL mRNA expression (i.e., log2 derived from the Allen Brain Atlas) within the identical 34 atlas regions. Yellow colors indicate higher KL mRNA expression. d Thresholded spatial maps restricted to regions falling above the 75th percentile of KL mRNA expression. e Scatterplot depicting the association between ROI-based KL mRNA expression and KL-VS^het × amyloid-PET interaction effect on regional tau-PET uptake. Statistical results are derived from the Pearson correlation (two-sided). Linear model fits are indicated together with 95% confidence intervals. Source data are provided as a Source Data file.