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. 2021 Jun 22;11:13045. doi: 10.1038/s41598-021-91025-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A comparison of DotMotif query syntax and the equivalent queries when transpiled to Cypher using the Neo4jExecutor. (a) A simple query to find inputs to Kenyon cells (KC) from the medial antennal lobe tracts (mALT) in the Hemibrain dataset. Note that DotMotif comments are notated with the hash character. (b) The equivalent query as panel (a), when converted to the Cypher query language for use with neuPrint systems. Even in a small query such as this, DotMotif syntax tends to be more succinct and readable. (c) A simple DotMotif query for a repeated pattern with node and edge constraints. The motif includes a macro called BigInhibitsSmall, which establishes a connection between two neurons with a type edge-attribute of “GABA”, and with radius nodes attribute constraints on both neuron participants. This macro is reused multiple times in the final motif construction in order to avoid repetitive code. DotMotif automatically infers that nodes A and B are isomorphic (i.e. interchangeable), and that C and D are isomorphic. (d) DotMotif converts the query in panel (c) to the Cypher code in (d). The equivalent Cypher query is substantially longer and harder to maintain or edit, even in the case of this quite simple motif. It also requires explicit notation to avoid reporting duplicate motif automorphisms.