Table 1.
Supplementary examinations.
Test | Date of test | Result |
---|---|---|
MRI | 1992 | Normal |
2003 | 3 Tesla MRI normal | |
2007 | Slightly atrophy over the right frontoparietal region | |
2012 | More marked atrophy, most prominent in the right frontal lobe. Increased enhancement in different areas in the right hemisphere, some resembling edema | |
2016 | Increased atrophy in the right frontoparietal region | |
2019-April | Considerable loss of brain substance in the right hemisphere and in mesencephalon, pons and diffuse symmetrical atrophy of cerebellum. | |
2019- June | New edema with diffusion restriction in the right cortical parietooccipital region and in the right thalamus, representing ictal/ post ictal activity | |
2019-Septembre | Considerable loss of brain substance in the right hemisphere and in mesencephalon, pons and cerebellum - unchanged from April 2019 | |
Brain pathology | 2012 | Brain biopsy: reactive gliosis and nerve cell loss in the gray matter of the brain, slight lymphocyte infiltration. Immunostaining for B and T cells did not show any significant changes except for a few CD3 positive T-cells perivascularly. No increase in CD20 positive B-cells. |
Cerebrospinal fluid | 2000 | Slight increase in leucocytes |
2012/ 2013/2019 | Normal with regards to cell count, protein, glucose ratio. Encephalitis antibodies negative for: anti-NMDA, AMPA1, AMPA 2, Gabareceptor B1, Contactin-associated protein 2, Leucin-rich glioma- inactivated protein 1, anti-CASPR2, anti-DPPX | |
Blood tests | 1992–2020 | SR, CRP, white blood count: normal; encephalitis antibodies: Negative |
EEG | 2002 | Epileptiform discharges were present and most prominent in the right frontal region, but also seen in in the temporal region |
2019-June | Focal status epilepticus, with some clinical seizures starting in the right occipital region | |
2019-September | Slow (theta and delta) activity bilaterally, and additionally more focal slowing over the right frontotemporal region. Sharp waves were also seen in this region, but were less frequent than in July |