Table 2.
Association between metabolites concentration, lipid main fractions concentration and high-MBD BC cases, compared to low-MBD BC cases, in the 87 sets (EPIC Florence, low- vs high-MBD BC case–case study).
| Conditional logistic regressiona | Adjusted conditional logistic regressionb | ||||
|---|---|---|---|---|---|
| Odds ratio (95% CI) for 1 SD | p value | Odds ratio (95% CI) for 1 SD | p value | p value FDRc | |
| Metabolite (n = 15) | |||||
| Creatinine | 0.89 (0.65–1.23) | 0.490 | 0.82 (0.51–1.31) | 0.408 | NS |
| Alanine | 0.59 (0.42–0.83) | 0.003 | 0.61 (0.34–1.09) | 0.095 | NS |
| Creatine | 0.78 (0.56–1.09) | 0.149 | 0.73 (0.43–1.21) | 0.222 | NS |
| Glutamine | 1.05 (0.79–1.38) | 0.751 | 0.91 (0.59–1.39) | 0.654 | NS |
| Glycine | 1.34 (0.98–1.85) | 0.071 | 1.46 (0.91–2.34) | 0.113 | NS |
| Histidine | 1.02 (0.76–1.37) | 0.898 | 0.63 (0.36–1.08) | 0.095 | NS |
| Isoleucine | 0.73 (0.52–1.01) | 0.056 | 0.90 (0.56–1.45) | 0.669 | NS |
| Leucine | 0.71 (0.52–0.98) | 0.034 | 0.86 (0.53–1.39) | 0.533 | NS |
| Tyrosine | 0.59 (0.42–0.82) | 0.002 | 0.512 (0.27–0.94) | 0.031 | NS |
| Valine | 0.72 (0.53–0.99) | 0.044 | 0.89 (0.54–1.46) | 0.633 | NS |
| Acetic acid | 1.67 (1.19–2.35) | 0.003 | 1.47 (0.86–2.50) | 0.158 | NS |
| Citric acid | 1.33 (0.97–1.83) | 0.077 | 1.25 (0.80–1.94) | 0.331 | NS |
| Lactic acid | 0.69 (0.49–0.96) | 0.026 | 0.79 (0.46–1.35) | 0.385 | NS |
| Pyruvic acid | 0.59 (0.41–0.84) | 0.003 | 0.67 (0.39–1.16) | 0.155 | NS |
| Glucose | 0.83 (0.60–1.14) | 0.259 | 1.19 (0.71–1.97) | 0.508 | NS |
| Lipid main fractions (n = 7) | |||||
| Triglycerides | 0.67 (0.48–0.93) | 0.018 | 1.36 (0.77–2.39) | 0.286 | NS |
| Cholesterol | 0.76 (0.54–1.08) | 0.123 | 1.06 (0.67–1.68) | 0.793 | NS |
| LDL cholesterol | 0.84 (0.61–1.15) | 0.276 | 1.13 (0.71–1.79 | 0.608 | NS |
| HDL cholesterol | 1.23 (0.91–1.66) | 0.173 | 0.81 (0.52–1.26) | 0.348 | NS |
| APO A1 | 1.05 (0.78–1.40) | 0.756 | 0.85 (0.57–1.26) | 0.419 | NS |
| APO A2 | 0.92 (0.67–1.26) | 0.607 | 0.88 (0.56–1.36) | 0.554 | NS |
| APO B100 | 0.72 (0.51–1.02) | 0.068 | 1.23 (0.75–2.02) | 0.405 | NS |
aOdds ratios per standard deviation (SD) increase in metabolite concentration conditioned on age at cohort entry (± 5 years), type of mammographic examination (analogical/digital; negative/diagnostic) and year of mammographic examination (before/after 2000). Single metabolites and lipid main fractions separately added to the regression model.
bOdds ratios per standard deviation (SD) increase in metabolite concentration conditioned on age at cohort entry (± 5 years), type of mammographic examination (analogical/digital; negative/diagnostic) and year of mammographic examination (before/after 2000) and adjusted for age at diagnosis, number of full-term pregnancies, breastfeeding (yes/no), menopausal status at baseline, ER status, body mass index at baseline. Single metabolites and lipid main fractions separately added to the regression model.
cp values adjusted for false discovery rate (FDR) at α = 0,05 with Benjamini–Hochberg correction.