Table 3.
Association between lipoprotein subfractions concentration and high-MBD cases, compared to low-MBD BC cases, in the 87 sets (EPIC Florence, low- vs high-MBD BC case–case study).
| Conditional logistic regressiona | Adjusted conditional logistic regression b | ||||
|---|---|---|---|---|---|
| Odds ratio (95%CI) for 1 SD | p value | Odds ratio (95%CI) for 1 SD | p value | p value FDR c | |
| LipoproteinMainFractionsTrigVLDL | 0.65 (0.46–0.91) | 0.014 | 1.43 (0.79–2.61) | 0.238 | NS |
| LipoproteinMainFractionsCholVLDL | 0.68 (0.49–0.95) | 0.025 | 1.57 (0.86–2.85) | 0.141 | NS |
| LipoprMainFractionsFreeCholVLDL | 0.67 (0.47–0.93) | 0.018 | 1.47 (0.82–2.64) | 0.201 | NS |
| LipoproteinMainFractionsPhosVLDL | 0.66 (0.47–0.93) | 0.018 | 1.50 (0.82–2.73) | 0.186 | NS |
| LipoproteinMainFractionsApoBVLDL | 0.56 (0.33–0.96) | 0.035 | 1.47 (0.85–2.53) | 0.171 | NS |
| SubfractionsTriglyceridesVLDL1 | 0.50 (0.31–0.80) | 0.004 | 1.27 (0.63–2.56) | 0.511 | NS |
| SubfractionsTriglyceridesVLDL5 | 0.65 (0.46–0.92) | 0.015 | 0.88 (0.53–1.47) | 0.624 | NS |
| SubfractionsCholesterolVLDL1 | 0.60 (0.42–0.86) | 0.005 | 1.38 (0.75–2.52) | 0.304 | NS |
| SubfractionsCholesterolVLDL5 | 0.57 (0.33–0.98) | 0.042 | 1.05 (0.51–2.16) | 0.893 | NS |
| SubfractionsFreeCholesterolVLDL2 | 1.04 (0.77–1.41) | 0.790 | 2.05 (1.24–3.39) | 0.005 | NS |
| SubfractionsFreeCholesterolVLDL3 | 1.20 (0.87–1.66) | 0.256 | 1.92 (1.08–3.41) | 0.026 | NS |
| SubfractionsFreeCholesterolVLDL4 | 1.04 (0.77–1.40) | 0.818 | 1.72 (1.04–2.83) | 0.035 | NS |
| SubfractionsPhospholipidsVLDL1 | 0.55 (0.36–0.85) | 0.006 | 1.49 (0.75–2.98) | 0.259 | NS |
| SubfractionsPhospholipidsVLDL5 | 0.51 (0.28–0.90) | 0.021 | 1.02 (0.48–2.21) | 0.951 | NS |
aOdds ratios per standard deviation (SD) increase in metabolite concentration conditioned on age at cohort entry (± 5 years), type of mammographic examination (analogical/digital; negative/diagnostic) and year of mammographic examination (before/after 2000). Single lipoprotein subfractions separately added to the regression model.
bOdds ratios per standard deviation (SD) increase in metabolite concentration conditioned on age at cohort entry (± 5 years), type of mammographic examination (analogical/digital; negative/diagnostic) and year of mammographic examination (before/after 2000) and adjusted for age at diagnosis, number of full-term pregnancies, breastfeeding (yes/no), menopausal status, ER status, body mass index. Single lipoprotein subfractions separately added to the regression model.
cp values adjusted for false discovery rate (FDR) at α = 0.05 with Benjamini–Hochberg correction.