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. 2021 Jun 22;5:56. doi: 10.1038/s41698-021-00200-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Violin plots of the infiltration levels of TILs and EMT levels for different subtypes of four types of cancer. B Gene set enrichment analysis of CYT_high and CYT_low tumors in ovarian cancer and bladder cancer. C Correlation between expression of mesenchymal and epithelial marker genes and CYT across the different types of cancer. D Correlation between the infiltration levels of the 22 immune cell subpopulations and EMT scores across different types of cancer. E Expression heatmaps of 83 EMT-associated growth factors in cancer cell lines and immune cell lines. F Boxplots of expression of TGFB1, HGF, BMP1 and PDGFB in different cell groups. ***P < 0.001. CYT cytolytic activity, EMT epithelial-mesenchymal transition, TILs tumor-infiltrating leukocytes.