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. 2021 Jun 22;5:56. doi: 10.1038/s41698-021-00200-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Correlation between ECI and the infiltration of 22 immune cell subpopulations across 17 types of solid cancer. B Immunohistochemistry assay was performed to mark macrophages or CTLs and detect the expression of Vimentin in lung cancer. C Pearson correlation analysis was used to assess the correlation between Vimentin expression and macrophages or CTLs infiltration. D Distribution of relative infiltration fraction of CD8+ T, T helper cells, M1 and M2 macrophages cells in different cancer subtypes of ovarian cancer and head and neck squamous cell carcinoma. E Unsupervised cluster of pan-cancer tumor samples using uniform manifold approximation and projection based on the relative infiltration fraction of the 22 immune cell subpopulations. F Relative fraction of infiltrating immune cells positively or negatively correlated with ECI across the 17 types of solid cancer. Tumors are ordered by the ratio of infiltrating immune cells negatively correlated with ECI (blue color) vs. infiltrating immune cells positively correlated with ECI (red color). ECI EMT-CYT index, EMT epithelial-mesenchymal transition.