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Observed (symbols) and model predicted (lines) cortisol plasma concentration-time courses following intravenous administration (left plots) of 1 mg/kg prednisolone succinate (1A) or saline (2A) and after the last oral (right plots) dose (216 h after first dose) of ~1 mg/kg for 10 consecutive daily doses orally (1B) or placebo (2B) to 9 beagle dogs.
